Chemistry:Flumexadol

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Short description: Chemical compound
Flumexadol
Flumexadol structure.svg
Clinical data
ATC code
  • None
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC11H12F3NO
Molar mass231.218 g·mol−1
3D model (JSmol)

Flumexadol (INN) (developmental code name CERM-1841 or 1841-CERM) is a drug described and researched as a non-opioid analgesic which was never marketed.[1][2][3][4] It has been found to act as an agonist of the serotonin 5-HT1A (pKi = 7.1) and 5-HT2C (pKi = 7.5) receptors and, to a much lesser extent, of the 5-HT2A (pKi = 6.0) receptor.[5][6] According to Nilsson (2006) in a paper on 5-HT2C receptor agonists as potential anorectics, "The (+)-enantiomer of this compound showed [...] affinity for the 5-HT2C receptor (Ki) 25 nM) [...] and was 40-fold selective over the 5-HT2A receptor in receptor binding studies. Curiously, the racemic version [...], also known as 1841 CERM, was originally reported to possess analgesic properties while no association with 5-HT2C receptor activity was mentioned."[4] It is implied that flumexadol might be employable as an anorectic in addition to analgesic.[4] Though flumexadol itself has never been approved for medical use, oxaflozane (brand name Conflictan) is a prodrug of the compound that was formerly used clinically in France as an antidepressant and anxiolytic agent.[5][7][8]

Synthesis

Thieme Synthesis:[9] Patent:[10]

Ex 1: Halogenation of 2-chloro ethyl vinyl ether [110-75-8] (1) with molecular bromine gives 1,2-dibromo-1-(2-chloroethoxy)ethane [14689-94-2] (2). Grignard reaction with 3-bromobenzotrifluoride [401-78-5] (3) gives 1-[2-Bromo-1-(2-chloroethoxy)ethyl]-3-(trifluoromethyl)benzene, CID:12343529 (4).

Ex 4: Treatment with benzylamine gives 4-benzyl-2-[3-(trifluoromethyl) phenyl]morpholine, CID:213531 (5).

Ex 6: Catalytric hydrogenation strips the benzyl protecting group completing the synthesis of flumexadol (6).

See also

References

  1. ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 561–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA561. 
  2. ↑ "The pharmacology of 1841 CERM, a new analgesic". Arzneimittel-Forschung 28 (4): 642–645. 1978. PMID 312104. 
  3. ↑ "Metabolites of 2-(3-trifluoromethylphenyl)tetrahydro-1,4-oxazine (CERM) 1841) in rats and dogs". Xenobiotica; the Fate of Foreign Compounds in Biological Systems 9 (11): 703–711. November 1979. doi:10.3109/00498257909042338. PMID 532219. 
  4. ↑ 4.0 4.1 4.2 "5-Hydroxytryptamine 2C (5-HT2C) receptor agonists as potential antiobesity agents". Journal of Medicinal Chemistry 49 (14): 4023–4034. July 2006. doi:10.1021/jm058240i. PMID 16821762. 
  5. ↑ 5.0 5.1 Bioorganic and Medicinal Chemistry of Fluorine. John Wiley & Sons. 2 June 2008. pp. 303–. ISBN 978-0-470-28187-1. https://books.google.com/books?id=QMVSvZ-R7I0C&pg=PA303. 
  6. ↑ "Selective 5-HT2C agonists as potential antidepressants". IDrugs 2 (2): 109–120. February 1999. PMID 16160946. 
  7. ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 909–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA909. 
  8. ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 766. ISBN 3-88763-075-0. https://books.google.com/books?id=5GpcTQD_L2oC&q=oxaflozane%20conflictan&pg=PA766. 
  9. ↑ "Tetrahydro-1, 4-Oxazines. I. New Synthesis Method and a Study of Their Interaction With Tryptaminergic D Receptors". European Journal of Medicinal Chemistry 11: 201–207. 1976. 
  10. ↑ "Process for the synthesis of 2-4-disubstituted tetrahydro 1,4-oxazines" FR patent 95182, assigned to Centre Europeen de Recherches Mauvernay CERM



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