Chemistry:SCHEMBL5334361

Short description: Drug

SCHEMBL5334361

Identifiers
IUPAC name 7-[(3-methoxyphenoxy)methyl]-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS Number	959867-47-1 Y
PubChem CID	59027940
Chemical and physical data
Formula	C18H21NO2
Molar mass	283.371 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC1=CC(=CC=C1)OCC2=CC3=C(CCNCC3)C=C2
InChI InChI=1S/C18H21NO2/c1-20-17-3-2-4-18(12-17)21-13-14-5-6-15-7-9-19-10-8-16(15)11-14/h2-6,11-12,19H,7-10,13H2,1H3 Key:BFCIUKMUJQOSDE-UHFFFAOYSA-N

SCHEMBL5334361 is a drug which acts as an agonist at the 5-HT₂ family of serotonin receptors, and was developed for the treatment of glaucoma. It is a benzazepine derivative structurally related to the anorectic drug lorcaserin. It is selective for 5-HT_2A, with an EC₅₀ of 0.4nM at 5-HT_2A vs 3.9nM at 5-HT_2C and a much lower affinity of 417nM at 5-HT_2B.

See also

• 3C-BZ
• AAZ-A-154
• AL-34662
• GSK-189254
• IHCH-7113
• O-4310