Chemistry:AVN-101

AVN-101
Identifiers
	IUPAC name 2,8-Dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;
CAS Number	1025725-91-0 ; 1061354-48-0 (hydrochloride);
ChemSpider	24643855;
UNII	6MHR5IV28S;
ChEMBL	ChEMBL592752;
Chemical and physical data
Formula	C21H24N2
Molar mass	304.437 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1ccc2c(c1)c3c(n2CCc4ccccc4)CCN(C3)C;
	InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3; Key:IBUHDDLETPJVGP-UHFFFAOYSA-N;

Short description: Chemical compound

AVN-101, a close structural analogue of latrepirdine, is a selective 5-HT₆ receptor antagonist which is under development by Avineuro Pharmaceuticals for the treatment of Alzheimer's disease and anxiety disorders.^[1]^[2]^[3] As of November 2013, it was in phase II clinical trials for these indications.^[2]^[3]^[4]^{[needs update]}

References

↑ "Small Molecule 5-HT6R Ligands: A Comprehensive Insight into their Selectivity and Activity". Current Bioactive Compounds 9 (1): 64–100. 2013. doi:10.2174/1573407211309010007. ISSN 1573-4072.
↑ ^2.0 ^2.1 "50 years of hurdles and hope in anxiolytic drug discovery". Nature Reviews. Drug Discovery 12 (9): 667–87. September 2013. doi:10.1038/nrd4075. PMID 23989795.
↑ ^3.0 ^3.1 "Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease". Journal of Medicinal Chemistry 57 (17): 7160–81. September 2014. doi:10.1021/jm5003952. PMID 24850589.
↑ "AVN 101". AdisInsight. http://adisinsight.springer.com/drugs/800030006.

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Identifiers

IUPAC name 2,8-Dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
CAS Number	1025725-91-0^Y 1061354-48-0 (hydrochloride)
ChemSpider	24643855
UNII	6MHR5IV28S
ChEMBL	ChEMBL592752
Chemical and physical data
Formula	C₂₁H₂₄N₂
Molar mass	304.437 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Cc1ccc2c(c1)c3c(n2CCc4ccccc4)CCN(C3)C
InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3 Key:IBUHDDLETPJVGP-UHFFFAOYSA-N