Chemistry:AR-A000002

AR-A000002
Clinical data
ATC code	none;
Identifiers
	IUPAC name (R)-N-[5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide;
PubChem CID	9846516;
ChemSpider	8022230;
UNII	L3CZ2XB4ER;
Chemical and physical data
Formula	C27H36N4O2
Molar mass	448.611 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C5COCCN5c(cc4)ccc4C(=O)NC2CCc1c(C2)c(ccc1C)N3CCN(C)CC3;
	InChI InChI=1S/C27H36N4O2/c1-20-3-10-26(31-13-11-29(2)12-14-31)25-19-22(6-9-24(20)25)28-27(32)21-4-7-23(8-5-21)30-15-17-33-18-16-30/h3-5,7-8,10,22H,6,9,11-19H2,1-2H3,(H,28,32)/t22-/m1/s1; Key:IHDRUIHIJWCTIY-JOCHJYFZSA-N;
	(verify)

Short description: Chemical compound

AR-A000002 is a drug which is one of the first compounds developed to act as a selective antagonist for the serotonin receptor 5-HT_1B,^[1] with approximately 10x selectivity for 5-HT_1B over the closely related 5-HT_1D receptor.^[2] It has been shown to produce sustained increases in levels of serotonin in the brain, and has anxiolytic effects in animal studies.^[3]^[4]

References

↑ "Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist". The Journal of Pharmacology and Experimental Therapeutics 304 (3): 1072–84. March 2003. doi:10.1124/jpet.102.045468. PMID 12604684.
↑ "In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist". European Journal of Pharmacology 499 (1–2): 67–75. September 2004. doi:10.1016/j.ejphar.2004.07.067. PMID 15363952.
↑ "Effects of long-term administration of the 5-hydroxytryptamine1B receptor antagonist AR-A000002 to guinea pigs". Psychopharmacology 172 (3): 333–40. March 2004. doi:10.1007/s00213-003-1667-8. PMID 14652708.
↑ "Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002". Naunyn-Schmiedeberg's Archives of Pharmacology 369 (3): 330–7. March 2004. doi:10.1007/s00210-004-0866-0. PMID 14758468.

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Original source: https://en.wikipedia.org/wiki/AR-A000002. Read more

[1] "Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist". The Journal of Pharmacology and Experimental Therapeutics 304 (3): 1072–84. March 2003. doi:10.1124/jpet.102.045468. PMID 12604684.

[2] "In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist". European Journal of Pharmacology 499 (1–2): 67–75. September 2004. doi:10.1016/j.ejphar.2004.07.067. PMID 15363952.

[3] "Effects of long-term administration of the 5-hydroxytryptamine1B receptor antagonist AR-A000002 to guinea pigs". Psychopharmacology 172 (3): 333–40. March 2004. doi:10.1007/s00213-003-1667-8. PMID 14652708.

[4] "Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002". Naunyn-Schmiedeberg's Archives of Pharmacology 369 (3): 330–7. March 2004. doi:10.1007/s00210-004-0866-0. PMID 14758468.

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v t e Anxiolytics (N05B)
5-HT_1AR agonists	Buspirone Gepirone^† Tandospirone
GABA_AR PAMs	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem^‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Chlormezanone^‡ Ethanol (alcohol) Etifoxine Imepitoin; Herbs: Kava Skullcap Valerian
Gabapentinoids (α₂δ VDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIs (e.g., escitalopram) SNRIs (e.g., duloxetine) SARIs (e.g., trazodone) TCAs (e.g., clomipramine^#) TeCAs (e.g., mirtazapine) MAOIs (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol)
Others	Benzoctamine Cannabidiol Cycloserine Fabomotizole Hydroxyzine Kanna Lavender Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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Clinical data

ATC code	none
Identifiers
IUPAC name (R)-N-[5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide
PubChem CID	9846516
ChemSpider	8022230
UNII	L3CZ2XB4ER
Chemical and physical data
Formula	C₂₇H₃₆N₄O₂
Molar mass	448.611 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C5COCCN5c(cc4)ccc4C(=O)NC2CCc1c(C2)c(ccc1C)N3CCN(C)CC3
InChI InChI=1S/C27H36N4O2/c1-20-3-10-26(31-13-11-29(2)12-14-31)25-19-22(6-9-24(20)25)28-27(32)21-4-7-23(8-5-21)30-15-17-33-18-16-30/h3-5,7-8,10,22H,6,9,11-19H2,1-2H3,(H,28,32)/t22-/m1/s1 Key:IHDRUIHIJWCTIY-JOCHJYFZSA-N
(verify)

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