Chemistry:Dazopride

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Short description: Chemical compound
Dazopride
Dazopride.svg
Clinical data
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC15H23ClN4O2
Molar mass326.83 g·mol−1

Dazopride (AHR-5531) is an antiemetic and gastroprokinetic agent of the benzamide class which was never marketed.[1][2][3][4][5] It acts as a 5-HT3 receptor antagonist and 5-HT4 receptor agonist.[3][4][6] In addition to its gastrointestinal effects, dazopride facilitates learning and memory in mice.[7]

See also

References

  1. ↑ "Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy". Cancer Chemotherapy and Pharmacology 31 (6): 442–444. 1993. doi:10.1007/bf00685032. PMID 8453682. 
  2. ↑ "Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility". Digestive Diseases and Sciences 31 (5): 524–529. May 1986. doi:10.1007/bf01320319. PMID 3698769. 
  3. ↑ 3.0 3.1 "The action of dazopride to enhance gastric emptying and block emesis". Neuropharmacology 26 (7A): 669–677. July 1987. doi:10.1016/0028-3908(87)90227-9. PMID 3114664. 
  4. ↑ 4.0 4.1 "Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs". Neuropharmacology 26 (9): 1321–1326. September 1987. doi:10.1016/0028-3908(87)90094-3. PMID 2890117. 
  5. ↑ Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. 1996. ISBN 0-412-46630-9. https://books.google.com/books?id=DeX7jgInYFMC&q=dazopride&pg=RA1-PA572. 
  6. ↑ "Further characterization, by use of tryptamine and benzamide derivatives, of the putative 5-HT4 receptor mediating tachycardia in the pig". British Journal of Pharmacology 102 (1): 107–112. January 1991. doi:10.1111/j.1476-5381.1991.tb12140.x. PMID 2043916. 
  7. ↑ Pharmacotherapy for mood, anxiety, and cognitive disorders. Washington, DC: American Psychiatric Press. 2000. ISBN 0-88048-885-9. https://books.google.com/books?id=lkmYfaO3RicC&q=dazopride%20memory&pg=RA1-PA547. 



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