Chemistry:S-14671

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Short description: Chemical compound
S-14671
Skeletal formula of S-14671
Space-filling model of the S-14671 molecule
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
Chemical and physical data
FormulaC22H25N3O2S
Molar mass395.52 g·mol−1

S-14671 is a naphthylpiperazine derivative which acts as a 5-HT1A receptor agonist (pKi = 9.3) with high efficacy and exceptional in vivo potency, and also as a 5-HT2A and 5-HT2C receptor antagonist (both are pKi = 7.8).[1][2] It displays only low and non-significant affinity for 5-HT1B and 5-HT3 sites.[2]

In producing 5-HT1A-mediated effects such as hypothermia and spontaneous tail flicks in rodents, S-14671 is active at doses as low as 5 µg subcutaneously, and is about 10-fold more potent than 8-OH-DPAT and 100-fold more potent than flesinoxan and buspirone.[1][2] Other 5-HT1A-mediated effects of S-14671 include induction of flat-body posture, corticosterone secretion, inhibition of morphine-induced antinociception, and attenuation of the electrical activity of the dorsal raphe nucleus.[2]

S-14671 has been found to possess powerful efficacy in the rodent forced swim test and in the pigeon conflict test, indicating marked antidepressant and anxiolytic effects, respectively, of which are also 5-HT1A-mediated.[3][4] It has never been trialed in humans, perhaps due to its potency being too great.[citation needed]

See also

References

  1. ↑ 1.0 1.1 "S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency". European Journal of Pharmacology 203 (2): 319–22. October 1991. doi:10.1016/0014-2999(91)90734-8. PMID 1839284. 
  2. ↑ 2.0 2.1 2.2 2.3 "S 14671: a naphtylpiperazine 5-hydroxytryptamine1A agonist of exceptional potency and high efficacy possessing antagonist activity at 5-hydroxytryptamine1C/2 receptors". The Journal of Pharmacology and Experimental Therapeutics 262 (2): 451–63. August 1992. PMID 1323650. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=1323650. 
  3. ↑ "The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists". European Journal of Pharmacology 271 (2–3): 537–41. December 1994. doi:10.1016/0014-2999(94)90816-8. PMID 7705455. 
  4. ↑ "Involvement of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test". Pharmacology Biochemistry and Behavior 51 (2–3): 211–5. 1995. doi:10.1016/0091-3057(94)00421-E. PMID 7667330. 



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