Chemistry:SB-204741

SB-204741
Clinical data
Other names	SB-204,741
Identifiers
	IUPAC name N-(1-Methyl-1H-indol-5-yl)-N'-(3-methylisothiazol-5-yl)urea;
CAS Number	152239-46-8 ;
PubChem CID	3277600;
IUPHAR/BPS	221;
ChemSpider	2526822;
UNII	9VHM49MS42;
ChEBI	CHEBI:140936;
Chemical and physical data
Formula	C14H14N4OS
Molar mass	286.35 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c2c(C)nsc2NC(=O)Nc3ccc1n(C)ccc1c3;
	InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19); Key:USFUFHFQWXDVMH-UHFFFAOYSA-N;
	(verify)

Short description: Chemical compound

SB-204741 is a drug which acts as a potent and selective antagonist at the serotonin 5-HT_2B receptor, with around 135x selectivity over the closely related 5-HT_2C receptor, and even higher over the 5-HT_2A receptor and other targets.^[1] It is used in scientific research for investigating the functions of the 5-HT_2B receptor.^[2]^[3]^[4]^[5]

References

↑ "N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist". Journal of Medicinal Chemistry 38 (6): 855–7. March 1995. doi:10.1021/jm00006a001. PMID 7699699.
↑ "Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT(2B) receptors". British Journal of Pharmacology 130 (3): 692–8. June 2000. doi:10.1038/sj.bjp.0703341. PMID 10821800.
↑ "Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones". British Journal of Pharmacology 143 (3): 351–60. October 2004. doi:10.1038/sj.bjp.0705935. PMID 15339859.
↑ "Stimulation of growth hormone release by 5-hydroxytryptamine (5-HT) in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors". Endocrinology 148 (9): 4509–22. September 2007. doi:10.1210/en.2007-0034. PMID 17584957.
↑ "Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors". Gastroenterology 133 (3): 897–906. September 2007. doi:10.1053/j.gastro.2007.06.017. PMID 17854596. https://lirias.kuleuven.be/bitstream/123456789/160659/1/2007+Gastro+5-HT.pdf.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/SB-204741. Read more

[1] "N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist". Journal of Medicinal Chemistry 38 (6): 855–7. March 1995. doi:10.1021/jm00006a001. PMID 7699699.

[2] "Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT(2B) receptors". British Journal of Pharmacology 130 (3): 692–8. June 2000. doi:10.1038/sj.bjp.0703341. PMID 10821800.

[3] "Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones". British Journal of Pharmacology 143 (3): 351–60. October 2004. doi:10.1038/sj.bjp.0705935. PMID 15339859.

[4] "Stimulation of growth hormone release by 5-hydroxytryptamine (5-HT) in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors". Endocrinology 148 (9): 4509–22. September 2007. doi:10.1210/en.2007-0034. PMID 17584957.

[5] "Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors". Gastroenterology 133 (3): 897–906. September 2007. doi:10.1053/j.gastro.2007.06.017. PMID 17854596. https://lirias.kuleuven.be/bitstream/123456789/160659/1/2007+Gastro+5-HT.pdf.

[1]

[2]

[3]

[4]

[5]

Anonymous

Search

Chemistry:SB-204741

Namespaces

More

Page actions

References

Navigation

Navigation

Help

Translate

Wiki tools

Wiki tools

Anonymous

Search

Chemistry:SB-204741

References

Navigation

Wiki tools

Page tools

Other projects

Categories