Chemistry:Lerisetron

Lerisetron
Clinical data
Other names	F-0930-RS
ATC code	None;
Identifiers
	IUPAC name 1-Benzyl-2-piperazin-1-yl-1H-benzimidazole;
CAS Number	143257-98-1 ;
PubChem CID	65997;
ChemSpider	59389 ;
UNII	Q36R82SXRG;
ChEMBL	ChEMBL56900 ;
Chemical and physical data
Formula	C18H20N4
Molar mass	292.386 g·mol−1
	InChI InChI=1S/C18H20N4/c1-2-6-15(7-3-1)14-22-17-9-5-4-8-16(17)20-18(22)21-12-10-19-11-13-21/h1-9,19H,10-14H2 ; Key:PWWDCRQZITYKDV-UHFFFAOYSA-N ;
	(what is this?) (verify)

Short description: Chemical compound

Lerisetron (code name F-0930-RS) is a drug which acts as an antagonist at the 5-HT₃ receptor.^[1] It is a potent antiemetic^[2]^[3] and was in clinical trials for the treatment of nausea associated with cancer chemotherapy.^[4]

References

↑ "New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation". Journal of Medicinal Chemistry 40 (4): 586–93. February 1997. doi:10.1021/jm960442e. PMID 9046349.
↑ "Antiemetic effects of Lerisetron in radiation-induced emesis in the dog". Acta Oncologica 37 (7–8): 759–63. 1998. doi:10.1080/028418698430160. PMID 10050999.
↑ "Effects of lerisetron, a new 5-HT3 receptor antagonist, on ipecacuanha-induced emesis in healthy volunteers". Arzneimittel-Forschung 52 (9): 689–94. 2002. doi:10.1055/s-0031-1299952. PMID 12404884.
↑ "Lerisetron. FAES". Current Opinion in Investigational Drugs 4 (7): 874–7. July 2003. PMID 14619411.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Lerisetron. Read more