Chemistry:CP-93129

From HandWiki
Short description: Chemical compound
CP-93129
CP-93129 Structure.svg
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
Chemical and physical data
FormulaC12H13N3O
Molar mass215.256 g·mol−1
3D model (JSmol)

CP-93129 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 150x and 200x selectivity over the closely related 5-HT1D and 5-HT1A receptors.[1] It is used in the study of 5-HT1B receptors in the brain, particularly their role in modulating the release of other neurotransmitters.[2][3][4][5]

References

  1. ↑ "3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole". Journal of Medicinal Chemistry 33 (8): 2087–93. August 1990. doi:10.1021/jm00170a007. PMID 2374139. 
  2. ↑ "Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice". European Journal of Pharmacology 476 (1–2): 71–7. August 2003. doi:10.1016/s0014-2999(03)02154-x. PMID 12969751. 
  3. ↑ "Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats". European Neuropsychopharmacology 14 (3): 217–25. May 2004. doi:10.1016/S0924-977X(03)00106-8. PMID 15056481. 
  4. ↑ "5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus". Journal of Neurophysiology 93 (6): 3157–64. June 2005. doi:10.1152/jn.00770.2004. PMID 15716370. https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1252&context=vetscipapers. 
  5. ↑ "Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei". Journal of Neurophysiology 101 (3): 1361–74. March 2009. doi:10.1152/jn.90750.2008. PMID 19144744. 



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