Chemistry:SR-57227

From HandWiki
Short description: Chemical compound
SR-57227
SR-57227 structure.png
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
Chemical and physical data
FormulaC10H14ClN3
Molar mass211.69 g·mol−1
3D model (JSmol)

SR-57227 is a potent and selective agonist at the 5HT3 receptor, with high selectivity over other serotonin receptor subtypes and good blood–brain barrier penetration.[1][2][3][4]

References

  1. "SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo". European Journal of Pharmacology 237 (2–3): 299–309. June 1993. doi:10.1016/0014-2999(93)90282-M. PMID 7689975. 
  2. "Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists". Journal of Computer-Aided Molecular Design 18 (10): 651–64. October 2004. doi:10.1007/s10822-004-6259-0. PMID 15849995. 
  3. "Involvement of 5-HT receptors in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT receptor channel and binding study". Journal of Neurochemistry 99 (3): 976–88. November 2006. doi:10.1111/j.1471-4159.2006.04137.x. PMID 16942594. 
  4. "Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats". Behavioural Brain Research 256: 520–8. November 2013. doi:10.1016/j.bbr.2013.09.002. PMID 24016840.