Chemistry:2CBFly-NBOMe

From HandWiki

2CBFly-NBOMe, also known as NBOMe-2C-B-FLY or as Cimbi-31, is a serotonin receptor modulator of the phenethylamine, DOx, and FLY families. It was indirectly derived from the phenethylamine hallucinogen 2C-B is and related to benzodifurans like 2C-B-FLY and N-benzylphenethylamines like 25B-NBOMe.

Interactions

Pharmacology

Pharmacodynamics

2CBFly-NBOMe acts as a potent partial agonist for the 5-HT2A serotonin receptor subtype.[1][2][3]

Chemistry

Analogues

Analogues of 2CBFly-NBOMe include 2C-B-FLY and 25B-NBOMe, among others.

History

2CBFly-NBOMe was discovered in 2002,[4] and further researched by Ralf Heim at the Free University of Berlin,[5] and subsequently investigated in more detail by a team at Purdue University led by David E. Nichols.[6]

Society and culture

Canada

2CBFly-NBOMe is a controlled substance in Canada under phenethylamine blanket-ban language.[7]

United Kingdom

This substance is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause in the Misuse of Drugs Act 1971.[8]


United States

2CBFly-NBOMe is not an explicitly controlled substance in the United States.[9] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

2CBFly-NBOMe is a controlled substance in Vermont as of January 2016.[10]

See also

  • 25-NB (psychedelics)
  • FLY (psychedelics)

References

  1. ↑ "Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor". Journal of Computer-Aided Molecular Design 25 (1): 51–66. January 2011. doi:10.1007/s10822-010-9400-2. PMID 21088982. Bibcode: 2011JCAMD..25...51S. 
  2. ↑ "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT (2A) agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging 38 (4): 681–93. April 2011. doi:10.1007/s00259-010-1686-8. PMID 21174090. 
  3. ↑ Hansen M (2011). Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain (PhD.). University of Copenhagen. Archived from the original on 2013-10-22. Retrieved 2012-11-02.
  4. ↑ "Development of highly potent partial agonists and chiral antagonists as tools for the study of 5-HT2A-receptor mediated function". Naunyn-Schmiedeberg's Archives of Pharmacology 365 (1 Suppl): R21–R40. 2002. doi:10.1007/s00210-002-0604-4. 
  5. ↑ Heim R (2004). Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts (PhD.). Free University of Berlin.
  6. ↑ Braden MR (2007). Towards a biophysical understanding of hallucinogen action (PhD.). Purdue University. ProQuest 304838368.
  7. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 
  8. ↑ "The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014" (in en). http://www.legislation.gov.uk/uksi/2014/1106/made. 
  9. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf 
  10. ↑ "Regulated Drugs Rule". Vermont Department of Health. http://healthvermont.gov/regs/documents/regulated_drugs_rule_20160101.pdf. 



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