Chemistry:WAY-208466

From HandWiki
Short description: Chemical compound
WAY-208466
Skeletal formula of WAY-208,466
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC17H18FN3O2S
Molar mass347.41 g·mol−1
3D model (JSmol)

WAY-208466 is a potent and highly selective full agonist of the 5-HT6 receptor.[1] It increases GABA levels in the cerebral cortex and tolerance does not appear to occur to this action upon chronic administration.[1] Animal studies have shown that WAY-208466 produces antidepressant and anxiolytic effects in rodents and it may also be useful in the treatment of obsessive-compulsive disorder.[1][2]

See also

References

  1. 1.0 1.1 1.2 "Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466". Neuropsychopharmacology 33 (6): 1323–35. May 2008. doi:10.1038/sj.npp.1301503. PMID 17625499. 
  2. "Antidepressant and anxiolytic effects of selective 5-HT(6) receptor agonists in rats". Psychopharmacology 213 (2–3): 499–507. March 2010. doi:10.1007/s00213-010-1798-7. PMID 20217056.