Chemistry:RH-34

Short description: Chemical compound

RH-34

Clinical data
Routes of administration	?
ATC code	none
Legal status
Legal status	BR: F2 In general: uncontrolled
Identifiers
IUPAC name 3-[2-(2-methoxybenzylamino)ethyl]-1H-quinazoline-2,4-dione
CAS Number	1028307-48-3 N
PubChem CID	10041987
ChemSpider	8217551 N
UNII	A31AED225O
Chemical and physical data
Formula	C18H19N3O3
Molar mass	325.368 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C1C=2C(NC(=O)N1CCNCC3=C(OC)C=CC=C3)=CC=CC2
InChI InChI=1S/C18H19N3O3/c1-24-16-9-5-2-6-13(16)12-19-10-11-21-17(22)14-7-3-4-8-15(14)20-18(21)23/h2-9,19H,10-12H2,1H3,(H,20,23) N Key:NUAJBITWGGTZCM-UHFFFAOYSA-N N
NY (what is this?)  (verify)

RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT_2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT_2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT_2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT_2A affinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.

Legal status

RH-34 is a controlled substance in Hungary and Brazil.

See also

• 5-MeO-NBpBrT
• IHCH-7113
• Ketanserin
• Efavirenz