Chemistry:RH-34

From HandWiki

RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT2A affinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.[1][2][3]

Interactions

Chemistry

Analogues

Analogues of RH-34 with potent serotonin 5-HT2A receptor agonist activity such as WL567 and WL568 have been described.[4]

Chemical structures of RH-34 and analogues

Society and culture

RH-34 is a controlled substance in Hungary[5] and Brazil.[6] It is not a controlled substance in Canada as of 2025.[7] It is also not an explicitly controlled substance in the United States.[8]

See also

References

  1. ↑ Ralf Heim. Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts. (German)
  2. ↑ Maria Silva. Theoretical study of the interaction of agonists with the 5-HT2A receptor. Universität Regensburg, 2009.
  3. ↑ "Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor". Journal of Computer-aided Molecular Design 25 (1): 51–66. January 2011. doi:10.1007/s10822-010-9400-2. PMID 21088982. Bibcode: 2011JCAMD..25...51S. 
  4. ↑ "Quinolone alkyl amines as novel serotonin 2a receptor (5ht2ar) agonists". 7 October 2022. https://patents.google.com/patent/WO2023060255A1/en. 
  5. ↑ A Magyarországon megjelent, a Kábítószer és Kábítószer-függőség Európai Megfigyelő Központjának Korai Jelzőrendszerébe (EMCDDA EWS) 2005 óta bejelentett ellenőrzött anyagok büntetőjogi vonatkozású besorolása
  6. ↑ "Anvisa". http://portal.anvisa.gov.br/lista-de-substancias-sujeitas-a-controle-especial. 
  7. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 
  8. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf 



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