Chemistry:WAY-161503

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Short description: Chemical compound
WAY-161503
WAY-161503.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC11H11Cl2N3O
Molar mass272.13 g·mol−1
3D model (JSmol)

WAY-161503 is a full agonist of 5-HT2C receptors (Ki = 3.3 nM for displacement of DOI), ~6-fold less potent at 5-HT2A receptors (Ki = 18 nM) and 20-fold less potent at 5-HT2B receptors (Ki = 60 nM).[1] In functional studies, it stimulates calcium mobilization coupled to 5-HT2C, 5-HT2B, and 5-HT2A receptors with EC50 values of 0.8, 1.8, and 7 nM, respectively.[1] WAY-161503 has been reported to produce dose-dependent decreases in food intake in 24-hour fasted normal Sprague-Dawley rats, diet-induced obese mice, and obese Zucker rats with ED50 values of 1.9, 6.8, and 0.73 mg/kg, respectively.[1]

WAY-161503 has been used to examine the role of 5-HT2C receptors in rodent models of depression, locomotion, reinforcement, or motivated behaviors.[2][3]

References

  1. ↑ 1.0 1.1 1.2 "Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503". Brain Research 1073-1074: 240–51. February 2006. doi:10.1016/j.brainres.2005.12.052. PMID 16430874. 
  2. ↑ "Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(2C) receptors". The Journal of Pharmacology and Experimental Therapeutics 295 (3): 1120–6. December 2000. PMID 11082448. http://jpet.aspetjournals.org/content/295/3/1120.full. 
  3. ↑ "Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats". Behavioural Brain Research 197 (2): 323–30. February 2009. doi:10.1016/j.bbr.2008.08.034. PMID 18805442. 



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