Chemistry:EMD-386088

Short description: Chemical compound

EMD-386088

Clinical data
ATC code	none
Identifiers
IUPAC name 5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
CAS Number	54635-62-0 Y
PubChem CID	10131112
ChemSpider	8306627
Chemical and physical data
Formula	C14H14ClN2
Molar mass	245.73 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc2cc1c(cc2)[nH]c(C)c1C=3CCNCC=3
InChI InChI=1S/C14H15ClN2/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9/h2-4,8,16-17H,5-7H2,1H3 Key:BPPGPYJBCVXILI-UHFFFAOYSA-N
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EMD-386088 is an indole derivative which is used in scientific research. It acts as a potent 5-HT₆ receptor partial agonist, with a K_i of 1 nM, a significantly higher affinity than older 5-HT₆ agonists such as EMDT, although it possesses moderate affinity for the 5-HT₃ receptor as well. Subsequent research has determined that EMD-386088 is also a dopamine reuptake inhibitor and that this action is involved in the antidepressant-like effects of the drug in rodents.

EMD-386088 can be further reacted with a butyrophenone sidechain.

See also

• EMDT
• ST-1936
• Tepirindole