Chemistry:GW-803430

GW-803430
Clinical data
ATC code	none;
Identifiers
	IUPAC name 6-(4-chlorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one;
CAS Number	515141-51-2;
PubChem CID	9826520;
ChemSpider	8002263;
UNII	4R0136W1PR;
Chemical and physical data
Formula	C25H24ClN3O3S
Molar mass	482.00 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C5CCCN5CCOc3ccc(cc3OC)-n1cnc2cc(sc2c1=O)-c(cc4)ccc4Cl;
	InChI InChI=1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3; Key:MWULMTACIBZPGN-UHFFFAOYSA-N;
	(verify)

Short description: Chemical compound

GW-803430 (GW-3430) is a drug used in scientific research and is a selective non-peptide antagonist at the melanin concentrating hormone receptor MCH₁. In animal studies it has anxiolytic, antidepressant and anorectic effects.^[1]^[2]

References

↑ "Neuropeptide receptors: Novel therapeutic targets for depression and anxiety disorders.". Drugs of the Future 32 (9): 809. 2007. doi:10.1358/dof.2007.032.09.1131450.
↑ "Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression". The Journal of Pharmacology and Experimental Therapeutics 329 (2): 429–38. May 2009. doi:10.1124/jpet.108.143362. PMID 19182070.

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Original source: https://en.wikipedia.org/wiki/GW-803430. Read more

[1] "Neuropeptide receptors: Novel therapeutic targets for depression and anxiety disorders.". Drugs of the Future 32 (9): 809. 2007. doi:10.1358/dof.2007.032.09.1131450.

[pmid19182070-2] "Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression". The Journal of Pharmacology and Experimental Therapeutics 329 (2): 429–38. May 2009. doi:10.1124/jpet.108.143362. PMID 19182070.

[1]

[2]

v t e Anxiolytics (N05B)
5-HT_1AR agonists	Buspirone Gepirone^† Tandospirone
GABA_AR PAMs	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem^‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Chlormezanone^‡ Ethanol (alcohol) Etifoxine Imepitoin; Herbs: Kava Skullcap Valerian
Gabapentinoids (α₂δ VDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIs (e.g., escitalopram) SNRIs (e.g., duloxetine) SARIs (e.g., trazodone) TCAs (e.g., clomipramine^#) TeCAs (e.g., mirtazapine) MAOIs (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol)
Others	Benzoctamine Cannabidiol Cycloserine Fabomotizole Hydroxyzine Kanna Lavender Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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Clinical data

ATC code	none
Identifiers
IUPAC name 6-(4-chlorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one
CAS Number	515141-51-2
PubChem CID	9826520
ChemSpider	8002263
UNII	4R0136W1PR
Chemical and physical data
Formula	C₂₅H₂₄ClN₃O₃S
Molar mass	482.00 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C5CCCN5CCOc3ccc(cc3OC)-n1cnc2cc(sc2c1=O)-c(cc4)ccc4Cl
InChI InChI=1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3 Key:MWULMTACIBZPGN-UHFFFAOYSA-N
(verify)

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