Chemistry:Metrenperone

From HandWiki

Metrenperone (INN, USAN, BAN; developmental code name R-50970) is a serotonin 5-HT2 receptor antagonist which was never marketed.[1][2] The drug also shows lower affinity for the α1-adrenergic and histamine H1 receptor and much lower affinity for the dopamine D2 receptor, but no affinity for the serotonin 5-HT1 and muscarinic acetylcholine receptors.[2] It is a weak antagonist of the α1-adrenergic receptor in addition to its potent serotonin 5-HT2A receptor antagonism.[3] Metrenperone has been investigated for use in veterinary medicine to treat acute respiratory distress in cattle and has also been studied for topical treatment of wounds as well as injuries.[1][4][5] It was first described in the scientific literature by 1982.[2]

See also

  • Serotonin 5-HT2A receptor antagonist

References

  1. ↑ 1.0 1.1 Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999. ISBN 978-0-7514-0499-9. https://books.google.com/books?id=mqaOMOtk61IC&pg=PA180. Retrieved 17 January 2026. 
  2. ↑ 2.0 2.1 2.2 "The Pharmacology of Specific, Pure and Potent Serotonin 5-HT2 or S2-Antagonists". Biochemical Immunological Pharmacology. Elsevier. 1982. pp. 21–33. doi:10.1016/b978-0-08-028024-0.50006-2. ISBN 978-0-08-028024-0. https://linkinghub.elsevier.com/retrieve/pii/B9780080280240500062. Retrieved 17 January 2026. 
  3. ↑ "Treatment of chronic myopathies in horses with the serotonin S 2 -antagonist R 50970: A preclinical study". Drug Development Research 8 (1–4): 219–224. 1986. doi:10.1002/ddr.430080126. ISSN 0272-4391. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/ddr.430080126. Retrieved 17 January 2026. 
  4. ↑ "Cardiovascular response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade, by metrenperone, in healthy calves". Veterinary Journal 157 (1): 31–37. January 1999. doi:10.1053/tvjl.1998.0250. PMID 10030126. 
  5. ↑ "Effects of a serotonin S2-receptor blocker on healing of acute and chronic tendon injuries". Journal of Investigative Surgery 22 (4): 246–255. 2009. doi:10.1080/08941930903040114. PMID 19842899. 



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