Chemistry:Trelanserin

From HandWiki

Trelanserin (INN; developmental code name SL 65.0472) is a dual serotonin 5-HT1B receptor antagonist and serotonin 5-HT2A receptor antagonist which was under development for the treatment of peripheral arterial occlusive disorders and thrombosis but was never marketed.[1][2][3][4] It is taken orally.[1] The drug was under development by Sanofi-Aventis.[1][2] It reached phase 2 clinical trials prior to the discontinuation of its development in 2009.[1][2][3] Trelanserin was first described in the scientific literature by 2000.[5]

See also

  • Serotonin 5-HT2A receptor antagonist

References

  1. ↑ 1.0 1.1 1.2 1.3 "SL 650472". 13 March 2009. https://adisinsight.springer.com/drugs/800014358. 
  2. ↑ 2.0 2.1 2.2 "Delving into the Latest Updates on Trelanserin with Synapse". 25 October 2025. https://synapse.patsnap.com/drug/23d44d396f0e45388844ca0aa89d8037. 
  3. ↑ 3.0 3.1 "Discontinued drugs in 2008: cardiovascular drugs". Expert Opinion on Investigational Drugs 18 (7): 875–885. July 2009. doi:10.1517/13543780903020308. PMID 19548849. "2.3.10 SL-65.0472 (SL-650472, SL650472) SL-65.0472 (SL-650472, SL650472; Sanofi-Aventis) is a 5HT1B/2A antagonist for the treatment of PAO. The molecule prevents local vasoconstriction and platelet aggregation and has antiproliferative activity at sites where atherosclerotic endothelium is present. The compound was in Phase IIb trial (MASCOT) in intermittent claudication Fontaine Stage II patients. However, it has been discontinued due to an inadequate risk–reward profile.". 
  4. ↑ "Antiplatelet and antithrombotic activity of SL65.0472, a mixed 5-HT1B/5-HT2A receptor antagonist". Thrombosis and Haemostasis (Thromb Haemost) 85 (3): 521–528. March 2001. doi:10.1055/s-0037-1615615. PMID 11307825. 
  5. ↑ "Effects of SL 65.0472, a novel 5-HT receptor antagonist, on 5-HT receptor mediated vascular contraction". European Journal of Pharmacology (Elsevier BV) 404 (3): 361–368. September 2000. doi:10.1016/s0014-2999(00)00630-0. PMID 10996601. 



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