Chemistry:WAY-161503

Short description: Chemical compound

WAY-161503

Identifiers
IUPAC name 8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one
CAS Number	75704-24-4
PubChem CID	3906894
ChemSpider	3130042
Chemical and physical data
Formula	C11H11Cl2N3O
Molar mass	272.13 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1cc2NC(=O)C3CNCCN3c2cc1Cl
InChI InChI=1S/C11H11Cl2N3O/c12-6-3-8-9(4-7(6)13)16-2-1-14-5-10(16)11(17)15-8/h3-4,10,14H,1-2,5H2,(H,15,17) Key:PHGWDAICBXUJDU-UHFFFAOYSA-N

WAY-161503 is a full agonist of 5-HT_2C receptors (Ki = 3.3 nM for displacement of DOI), ~6-fold less potent at 5-HT_2A receptors (Ki = 18 nM) and 20-fold less potent at 5-HT_2B receptors (Ki = 60 nM). In functional studies, it stimulates calcium mobilization coupled to 5-HT_2C, 5-HT_2B, and 5-HT_2A receptors with EC₅₀ values of 0.8, 1.8, and 7 nM, respectively. WAY-161503 has been reported to produce dose-dependent decreases in food intake in 24-hour fasted normal Sprague-Dawley rats, diet-induced obese mice, and obese Zucker rats with ED₅₀ values of 1.9, 6.8, and 0.73 mg/kg, respectively.

WAY-161503 has been used to examine the role of 5-HT_2C receptors in rodent models of depression, locomotion, reinforcement, or motivated behaviors.