Chemistry:SR-57227

SR-57227
Identifiers
	IUPAC name 1-(6-chloropyridin-2-yl)piperidin-4-amine;
CAS Number	77145-61-0;
PubChem CID	131747;
IUPHAR/BPS	4316;
ChemSpider	116402;
UNII	OW45B79UZD;
Chemical and physical data
Formula	C10H14ClN3
Molar mass	211.69 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClC1=CC=CC(N2CCC(N)CC2)=N1;
	InChI InChI=1S/C10H14ClN3/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14/h1-3,8H,4-7,12H2; Key:WPVVMKYQOMJPIN-UHFFFAOYSA-N;

Short description: Chemical compound

SR-57227 is a potent and selective agonist at the 5HT₃ receptor, with high selectivity over other serotonin receptor subtypes and good blood–brain barrier penetration.^[1]^[2]^[3]^[4]

References

↑ "SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo". European Journal of Pharmacology 237 (2–3): 299–309. June 1993. doi:10.1016/0014-2999(93)90282-M. PMID 7689975.
↑ "Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists". Journal of Computer-Aided Molecular Design 18 (10): 651–64. October 2004. doi:10.1007/s10822-004-6259-0. PMID 15849995.
↑ "Involvement of 5-HT receptors in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT receptor channel and binding study". Journal of Neurochemistry 99 (3): 976–88. November 2006. doi:10.1111/j.1471-4159.2006.04137.x. PMID 16942594.
↑ "Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats". Behavioural Brain Research 256: 520–8. November 2013. doi:10.1016/j.bbr.2013.09.002. PMID 24016840.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/SR-57227. Read more

Identifiers

IUPAC name 1-(6-chloropyridin-2-yl)piperidin-4-amine
CAS Number	77145-61-0
PubChem CID	131747
IUPHAR/BPS	4316
ChemSpider	116402
UNII	OW45B79UZD
Chemical and physical data
Formula	C₁₀H₁₄ClN₃
Molar mass	211.69 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES ClC1=CC=CC(N2CCC(N)CC2)=N1
InChI InChI=1S/C10H14ClN3/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14/h1-3,8H,4-7,12H2 Key:WPVVMKYQOMJPIN-UHFFFAOYSA-N