Chemistry:Glemanserin

Short description: Chemical compound

Glemanserin

Clinical data
ATC code	None
Identifiers
IUPAC name α-phenyl-1-(2-phenylethyl)-4-piperidine methanol
CAS Number	132553-86-7
PubChem CID	71781
ChemSpider	64815
UNII	X96LS7MC5Z
Chemical and physical data
Formula	C20H25NO
Molar mass	295.426 g·mol−1
3D model (JSmol)	Interactive image
SMILES OC(c1ccccc1)C3CCN(CCc2ccccc2)CC3
InChI InChI=1S/C20H25NO/c22-20(18-9-5-2-6-10-18)19-12-15-21(16-13-19)14-11-17-7-3-1-4-8-17/h1-10,19-20,22H,11-16H2 Key:AXNGJCOYCMDPQG-UHFFFAOYSA-N

Glemanserin (INN) (developmental code name MDL-11,939) is a drug which acts as a potent and selective 5-HT_2A receptor antagonist. The first truly selective 5-HT_2A ligand to be discovered, glemanserin resulted in the development of the widely used and even more potent and selective 5-HT_2A receptor antagonist volinanserin (MDL-100,907), which is a fluorinated analogue. Though it was largely superseded in scientific research by volinanserin, glemanserin was investigated clinically for the treatment of generalized anxiety disorder. However, it was ultimately found to be ineffective and was not marketed.

See also

• Volinanserin
• Pruvanserin
• Roluperidone
• Lenperone
• Lidanserin