Chemistry:A-CHMINACA

From HandWiki

A-CHMINACA, (ACHMINACA, Adamantyl-CHMINACA, SGT-37), is an indazole-based synthetic cannabinoid that binds to the CB1 and CB2 receptors.[1][2]

It has an EC50 of 159 nM for human CB1 receptors.[3]

Metabolism

A-CHMINACA is not hydrolized by human carboxylesterases which increases its half-life.[4]

Distribution

A-CHMINACA has been sold as a designer drug with one sample having been seized by Polish authorities in Lublin.[5]

It was also detected in samples taken in Toronto in 2020.[6]

See also

References

  1. ↑ "Substance Details Adamantyl-CHMINACA". https://www.unodc.org/LSS/Substance/Details/93d99217-f25e-4a00-8c61-fb771b02846c. 
  2. ↑ "New Psychoactive Substances: A Canadian perspective on emerging trends and challenges for the clinical laboratory". Clinical Biochemistry (Elsevier BV) 133-134. Dec 2024. doi:10.1016/j.clinbiochem.2024.110810. ISSN 0009-9120. PMID 39181179. 
  3. ↑ "Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA". ACS Chemical Neuroscience 11 (24): 4434–4446. December 16, 2020. doi:10.1021/acschemneuro.0c00644. ISSN 1948-7193. PMID 33253529. https://pubs.acs.org/doi/10.1021/acschemneuro.0c00644. Retrieved September 10, 2025. 
  4. ↑ "Going deeper into the toxicokinetics of synthetic cannabinoids: in vitro contribution of human carboxylesterases". Archives of Toxicology (Springer Science and Business Media LLC) 96 (10): 2755–2766. July 5, 2022. doi:10.1007/s00204-022-03332-z. ISSN 0340-5761. PMID 35788413. PMC 9352624. Bibcode: 2022ArTox..96.2755W. https://link.springer.com/content/pdf/10.1007/s00204-022-03332-z.pdf. Retrieved September 10, 2025. 
  5. ↑ "Comprehensive analytical characteristics of N-(adamantan-1-yl)-1- (cyclohexylmethyl)-1H-indazole-3-carboxamide (ACHMINACA)". Forensic Toxicology 39 (1): 230–239. 2021. doi:10.1007/s11419-020-00547-6. ISSN 1860-8965. https://link.springer.com/content/pdf/10.1007/s11419-020-00547-6.pdf. Retrieved September 10, 2025. 
  6. ↑ "Emerging synthetic cannabinoids detected by a drug checking service in Toronto, Canada". Clinical Toxicology 60 (8): 979–984. August 3, 2022. doi:10.1080/15563650.2022.2069575. ISSN 1556-3650. PMID 35546568. https://www.tandfonline.com/doi/full/10.1080/15563650.2022.2069575. Retrieved September 10, 2025. 



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