Chemistry:VIP36
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VIP36 is a synthetic cannabinoid derivative, closely related to the highly potent and neurotoxic designer drug MDMB-FUBINACA. However, unlike MDMB-FUBINACA, VIP36 has a positively charged N-alkoxyguanidine group attached which prevents it from crossing the blood-brain barrier. As a result, VIP36 is a highly peripherally selective drug - neurotoxic effects only became evident at 100x the estimated effective dose needed for analgesia.[1][2]
See also
References
- ↑ "A cryptic pocket in CB1 drives peripheral and functional selectivity". Nature 640 (8057): 265–273. April 2025. doi:10.1038/s41586-025-08618-7. PMID 40044849. Bibcode: 2025Natur.640..265R.
- ↑ "Designer cannabinoids could be the key to pain relief without adverse effects". Nature 640 (8057): 45–46. April 2025. doi:10.1038/d41586-025-00546-w. PMID 40045120. Bibcode: 2025Natur.640...45G.
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