Chemistry:CTW0404

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CTW0404 is an experimental drug which is described as a positive allosteric modulator of the 5-HT2A receptor, with neutral or negative modulation of the related 5-HT2B and 5-HT2C subtypes. It does not produce the head-twitch response in animal studies, and reduces the head-twitch response produced by DOI, suggesting that it may be a biased allosteric modulator selective for certain signalling pathways.[1][2][3][4]

See also

References

  1. ↑ "Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties". Journal of Medicinal Chemistry 63 (14): 7529–7544. July 2020. doi:10.1021/acs.jmedchem.9b01953. PMID 32567857. 
  2. ↑ "μ-opioid receptor agonists and psychedelics: pharmacological opportunities and challenges". Frontiers in Pharmacology 14. 2023. doi:10.3389/fphar.2023.1239159. PMID 37886127. 
  3. ↑ "Serendipitous Discovery of Novel 5-HT2AR Positive Allosteric Modulators (PAMs) Derived From 5-HT2CR PAM Scaffolds". The Journal of Pharmacology and Experimental Therapeutics 389: 87. 2024. doi:10.1124/jpet.087.985400. 
  4. ↑ Zhou J, Cunningham KA, Bolinger AA, Anastasio NC, "Novel heterocyclic compounds as serotonin (5-ht) 5-ht2a and 5-ht2c receptor positive allosteric modulators.", WO patent 2023/023287, published 22 February 2024



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