Chemistry:LY-266,097

LY-266,097
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 1-[(2-chloro-3,4-dimethoxyphenyl)methyl]-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole;
CAS Number	208591-60-0 ;
PubChem CID	9953185;
ChemSpider	8128795;
UNII	2Z9TC7YMY4;
ChEMBL	ChEMBL95121;
Chemical and physical data
Formula	C21H23ClN2O2
Molar mass	370.88 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC2=C(C=C1)NC3=C2CCNC3CC4=C(C(=C(C=C4)OC)OC)Cl;
	InChI InChI=1S/C21H23ClN2O2/c1-12-4-6-16-15(10-12)14-8-9-23-17(20(14)24-16)11-13-5-7-18(25-2)21(26-3)19(13)22/h4-7,10,17,23-24H,8-9,11H2,1-3H3; Key:NJLHHCITDFZZSE-UHFFFAOYSA-N;

Short description: Chemical compound

LY-266,097 is a research ligand which acts as a potent and selective antagonist for the 5-HT_2B receptor, with more than 100x selectivity over the related 5-HT_2A and 5-HT_2C receptor subtypes.^[1] It has been used to study the role of the 5-HT_2B receptor in modulating dopamine release in the brain,^[2]^[3] as well as its involvement in other processes such as allodynia.^[4]

References

↑ "Azithromycin has enhanced effects on lung fibroblasts from idiopathic pulmonary fibrosis (IPF) patients compared to controls [corrected"]. Respiratory Research 21 (1): 25. January 2020. doi:10.1186/s12931-020-1275-8. PMID 31941499.
↑ "The central serotonin 2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity". Journal of Neurochemistry 114 (5): 1323–1332. September 2010. doi:10.1111/j.1471-4159.2010.06848.x. PMID 20534001.
↑ "Differential control of dopamine ascending pathways by serotonin2B receptor antagonists: New opportunities for the treatment of schizophrenia". Neuropharmacology 109: 59–68. October 2016. doi:10.1016/j.neuropharm.2016.05.024. PMID 27260325.
↑ "5-HT_2B Receptor Antagonists Reduce Nerve Injury-Induced Tactile Allodynia and Expression of 5-HT_2B Receptors". Drug Development Research 76 (1): 31–39. February 2015. doi:10.1002/ddr.21238. PMID 25620128.

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Original source: https://en.wikipedia.org/wiki/LY-266,097. Read more

[pmid31941499-1] "Azithromycin has enhanced effects on lung fibroblasts from idiopathic pulmonary fibrosis (IPF) patients compared to controls [corrected"]. Respiratory Research 21 (1): 25. January 2020. doi:10.1186/s12931-020-1275-8. PMID 31941499.

[pmid20534001-2] "The central serotonin 2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity". Journal of Neurochemistry 114 (5): 1323–1332. September 2010. doi:10.1111/j.1471-4159.2010.06848.x. PMID 20534001.

[pmid27260325-3] "Differential control of dopamine ascending pathways by serotonin2B receptor antagonists: New opportunities for the treatment of schizophrenia". Neuropharmacology 109: 59–68. October 2016. doi:10.1016/j.neuropharm.2016.05.024. PMID 27260325.

[pmid25620128-4] "5-HT_2B Receptor Antagonists Reduce Nerve Injury-Induced Tactile Allodynia and Expression of 5-HT_2B Receptors". Drug Development Research 76 (1): 31–39. February 2015. doi:10.1002/ddr.21238. PMID 25620128.

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Legal status	In general: uncontrolled
Identifiers
IUPAC name 1-[(2-chloro-3,4-dimethoxyphenyl)methyl]-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
CAS Number	208591-60-0^Y
PubChem CID	9953185
ChemSpider	8128795
UNII	2Z9TC7YMY4
ChEMBL	ChEMBL95121
Chemical and physical data
Formula	C₂₁H₂₃ClN₂O₂
Molar mass	370.88 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=CC2=C(C=C1)NC3=C2CCNC3CC4=C(C(=C(C=C4)OC)OC)Cl
InChI InChI=1S/C21H23ClN2O2/c1-12-4-6-16-15(10-12)14-8-9-23-17(20(14)24-16)11-13-5-7-18(25-2)21(26-3)19(13)22/h4-7,10,17,23-24H,8-9,11H2,1-3H3 Key:NJLHHCITDFZZSE-UHFFFAOYSA-N

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