Chemistry:MDMB-5Br-INACA

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MDMB-5Br-INACA is an indazole-3-carboxamide derivative which has been sold as a designer drug.[1] Surprisingly it has been reported to produce psychoactive activity despite the lack of a "tail" group at the indazole 1-position, but is likely of relatively low potency as a CB1 agonist and has been encountered being misrepresented as other illicit drugs such as MDMA.[2][3] This reported psychoactive activity has been limitedly reported on but could be related to activity beyond the cannabinoid receptors due to vague structural relation to compounds like 1Z2MAP1O.

Use as a precursor

MDMB-5Br-INACA is believed to be used as a precursor in the synthesis of synthetic cannabinoids. It has been sold online as a "chemistry kit" with other compounds required to complete the reaction. This reaction would complete MDMB-5Br-INACA by giving it a "tail" group required for high cannabinoid activity. Other precursors lacking a tail chain have also been marketed such as (ADB-5-Br-INACA),[4] (CH-IATA), (ADB-IACA), and (ADB-5’Br-EZO-CA). This may be due to increasing legality changes worldwide on synthetic cannabinoids.[5][6]

Legality

In the United States, MDMB-5Br-INACA is unscheduled at the federal level as of May 22nd, 2023.

North Dakota has placed MDMB-5Br-INACA (along with ADB-5'Br-BINACA, ADB-5'Br-BUTINACA and ADB-5-Br-INACA) into Schedule I on 04/27/2023.[7]

See also

References

  1. ↑ "CFSRE Analysis Report". Indianapolis-Marion County Forensic Services Agency. 17 May 2022. https://www.npsdiscovery.org/wp-content/uploads/2022/05/MDMB-5Br-INACA_051722_CFSRE-Chemistry_Report.pdf. 
  2. ↑ "Drug testers warn of new synthetic cannabinoid being sold as MDMA". New Zealand Herald. 5 August 2022. https://www.nzherald.co.nz/nz/drug-testers-warn-of-new-synthetic-cannabinoid-being-sold-as-mdma/T35763CVQZHPV6LBZEQQ6FPX3U/. 
  3. ↑ "In vitro cannabinoid activity profiling of generic ban-evading brominated synthetic cannabinoid receptor agonists and their analogs". Drug Testing and Analysis 16 (6): 616–628. October 2023. doi:10.1002/dta.3592. PMID 37903509. 
  4. ↑ "Identification of a novel bromoindazole synthetic cannabinoid analogue in seized e-cigarette liquid: ADB-BRINACA". Forensic Science International 338. September 2022. doi:10.1016/j.forsciint.2022.111385. PMID 35863161. 
  5. ↑ "Cumyl-PeGaClone and other recently encountered synthetic cannabinoid receptor agonists. A review of the evidence on their use and harms.". Advisory Council on the Misuse of Drugs. 2022. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1159142/Cumyl-pegalone_and_other_uncontrolled_SCRA_report-FINAL.pdf. 
  6. ↑ "From JWH-018 to OXIZIDS: Structural evolution of synthetic cannabinoids in the European Union from 2008 to present day". Drug Testing and Analysis 15 (4): 378–387. April 2023. doi:10.1002/dta.3422. PMID 36507715. 
  7. ↑ "AN ACT to amend and reenact sections 19-03.1-05, 19-03.1-11, and 19-03.1-13 of the North Dakota Century Code, relating to the scheduling of controlled substances; and to declare an emergency.". Sixty-eighth Legislative Assembly of North Dakota in Regular Session. 3 January 2023. https://www.ndlegis.gov/prod/assembly/68-2023/regular/documents/23-8099-04000.pdf. 



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