Chemistry:SCQ1

From HandWiki
Short description: Chemical compound
SCQ1
SCQ1 structure.png
Identifiers
ChemSpider
Chemical and physical data
FormulaC19H19NO2
Molar mass293.366 g·mol−1
3D model (JSmol)

(S)-SCQ1 is a drug which acts as a potent and selective antagonist for the 5-HT2B and 5-HT2C serotonin receptors, but with only modest affinity for the closely related 5-HT2A receptor and other targets such as 5-HT7. Since most currently available 5-HT2 class ligands have relatively poor selectivity and bind to all three subtypes, the selectivity of (S)-SCQ1 is expected to be useful for studying 5-HT2A receptor mediated responses in the absence of 5-HT2B and 5-HT2C activation.[1]

See also

References

  1. ↑ "Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library". Journal of Medicinal Chemistry 66 (16): 11536–11554. August 2023. doi:10.1021/acs.jmedchem.3c01059. PMID 37566000. 



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