Chemistry:Z3517967757

Short description: Chemical compound

Z3517967757

Identifiers
IUPAC name 4-[1-(1-pyrimidin-2-ylethyl)piperidin-3-yl]phenol
CAS Number	none
PubChem CID	167949972
Chemical and physical data
Formula	C17H21N3O
Molar mass	283.375 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C1=NC=CC=N1)N2CCCC(C2)C3=CC=C(C=C3)O
InChI InChI=1S/C17H21N3O/c1-13(17-18-9-3-10-19-17)20-11-2-4-15(12-20)14-5-7-16(21)8-6-14/h3,5-10,13,15,21H,2,4,11-12H2,1H3 Key:JDCMEPNJYDYSCB-UHFFFAOYSA-N

Z3517967757 (Z7757) is a piperidine derivative which acts as an agonist at the 5-HT₂ family of serotonin receptors, first reported in 2024. It has strongest activity at 5-HT_2A and lower affinity at the 5-HT_2B and 5-HT_2C subtypes. It was developed using in silico modelling to dock a large library of compounds against a 5-HT_2A receptor model generated by the artificial intelligence program AlphaFold, and then synthesised and tested in the laboratory to confirm activity. It has two stereogenic centers and four possible isomers, but has only been tested as a racemic mixture.

See also

• AAZ-A-154
• (R)-69
• List of miscellaneous 5HT2A agonists