Chemistry:Doxpicomine
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Short description: Chemical compound
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| Routes of administration | Oral |
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| Formula | C12H18N2O2 |
| Molar mass | 222.288 g·mol−1 |
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Doxpicomine (Doxpicodin, Doxpizodine) is a mild opioid analgesic drug.[1] The drug acts as a mu-opioid receptor agonist.[2] It is of fairly low potency, with a 400 mg dose of doxpicomine approximately equivalent in pain-killing effect to 8 mg morphine or 100 mg pethidine.[3][4] It has been used as a lead compound to derive further analogues, although all compounds in this family are comparatively weak mu agonists.[5]
References
- ↑ Booher RN, "m-Dioxane-5-Methylamine Analgesics", US patent 3905987, issued 09/16/1975, assigned to Eli Lilly
- ↑ "Preclinical pharmacology of doxpicodin, a new analgesic". NIDA Research Monograph 34: 75–81. February 1981. PMID 6261137.
- ↑ "Doxpicomine in postoperative pain". Clinical Pharmacology and Therapeutics 29 (6): 771–5. June 1981. doi:10.1038/clpt.1981.109. PMID 7014073.
- ↑ "Further efficacy evaluation of doxpicomine for postoperative pain". Journal of Clinical Pharmacology 23 (1): 44–7. January 1983. doi:10.1002/j.1552-4604.1983.tb02703.x. PMID 6341416.
- ↑ "[Benzomorphan analogs with doxpicomine partial structure: synthesis andpsychopharmacologic investigations of 5-aminomethyl- and 5-(alpha-aminobenzyl)- substituted 2,6-epoxy-3-benzoxocines]" (in German). Archiv der Pharmazie 326 (3): 171–80. March 1993. doi:10.1002/ardp.19933260311. PMID 8481096.
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