Chemistry:Bezitramide
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| Routes of administration | Oral |
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| Formula | C31H32N4O2 |
| Molar mass | 492.623 g·mol−1 |
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Bezitramide is an opioid analgesic. Bezitramide itself is a prodrug which is readily hydrolyzed in the gastrointestinal tract to its active metabolite, despropionyl-bezitramide.[1] Bezitramide was discovered at Janssen Pharmaceutica in 1961.[2][3][4] It is most commonly marketed under the trade name Burgodin.
The drug was pulled from the shelves in the Netherlands in 2004 after fatal overdose cases, including one where a five-year-old child took one tablet from his mother's purse, ate it, and promptly died.[5]
Bezitramide is regulated much the same as morphine in all known jurisdictions and is a Schedule II substance under the United States' Controlled Substances Act of 1970, with an ACSCN of 9800 and zero annual manufacturing quota.[6] However, as of May 2021, it has never been marketed in the United States.
See also
References
- ↑ "Pharmacokinetics of the oral narcotic analgesic bezitramide and preliminary observations on its effect on experimentally induced pain". European Journal of Clinical Pharmacology 27 (5): 615–8. 1984. doi:10.1007/BF00556902. PMID 6519169.
- ↑ Janssen PA, "Benzimidalinyl Piperidines", US patent 3196157, published 1963-06-11, issued 1965-07-20
- ↑ "Bezitramide (R 4845), a new potent and orally long-acting analgesic compound". Arzneimittel-Forschung 21 (6): 862–7. June 1971. PMID 5109278.
- ↑ "Bezitramide, an orally active analgesic. An investigation on pain following operations for lumbar disc protrusion (preliminary report)". British Journal of Anaesthesia 42 (4): 325–8. April 1970. doi:10.1093/bja/42.4.325. PMID 4913411.
- ↑ "[Death caused by one tablet of Burgodin]". Nederlands Tijdschrift voor Geneeskunde 127 (34): 1552–3. August 1983. PMID 6633692.
- ↑ "Title 21 United States Code (USC) Controlled Substances Act". http://www.deadiversion.usdoj.gov/21cfr/21usc/812.htm.
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