Chemistry:CUMYL-FUBINACA
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Short description: Chemical compound
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| Formula | C24H22FN3O |
| Molar mass | 387.458 g·mol−1 |
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CUMYL-FUBINACA (SGT-149) is an indazole-3-carboxamide based synthetic cannabinoid receptor agonist, with an EC50 of 1.8nM for human CB1 receptors and 23.7nM for human CB2 receptors, giving it around 13x selectivity for CB1.[1][2][3][4] It has been sold online as a designer drug.[5]
See also
References
- ↑ Bowden MW, Williamson PB, "Cannabinoid compounds", WO patent 2014167530, published 11 April 2013
- ↑ "Pharmacology of Cumyl-Carboxamide Synthetic Cannabinoid New Psychoactive Substances (NPS) CUMYL-BICA, CUMYL-PICA, CUMYL-5F-PICA, CUMYL-5F-PINACA, and Their Analogues". ACS Chemical Neuroscience 8 (10): 2159–2167. October 2017. doi:10.1021/acschemneuro.7b00267. PMID 28792725.
- ↑ "The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substances: Evolution". New Psychoactive Substances. Handbook of Experimental Pharmacology. 252. 2018. pp. 191–226. doi:10.1007/164_2018_144. ISBN 978-3-030-10560-0.
- ↑ "Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex". Cell 176 (3): 448–458.e12. January 2019. doi:10.1016/j.cell.2018.11.040. PMID 30639101.
- ↑ "Surface internet marketplace presence and availability of NPS sold as research chemicals: a snapshot study.". Toxicology Communications 3 (1): 67–74. 2019. doi:10.1080/24734306.2019.1648067.
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