Chemistry:EG-018
From HandWiki
Short description: Chemical compound
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| Formula | C28H25NO |
| Molar mass | 391.514 g·mol−1 |
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EG-018 is a carbazole-based synthetic cannabinoid that has been sold online as a designer drug.[1][2][3][4][5] It acts as a partial agonist of the CB1 and CB2 receptor, with reasonably high binding affinity, but low efficacy in terms of inducing a signaling response.[6]
Legal status
EG-018 is a controlled substance in Japan.[7]
See also
References
- ↑ "EG 018". https://www.caymanchem.com/product/15533.
- ↑ "Phase I metabolism of the carbazole-derived synthetic cannabinoids EG-018, EG-2201, and MDMB-CHMCZCA and detection in human urine samples". Drug Testing and Analysis 10 (9): 1417–1429. September 2018. doi:10.1002/dta.2398. PMID 29726116.
- ↑ "The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substances: Evolution". New Psychoactive Substances. Handbook of Experimental Pharmacology. 252. Springer International Publishing. August 2018. pp. 191–226. doi:10.1007/164_2018_144. ISBN 978-3-030-10561-7.
- ↑ "In vitro metabolic profiling of synthetic cannabinoids by pooled human liver microsomes, cytochrome P450 isoenzymes, and Cunninghamella elegans and their detection in urine samples". Analytical and Bioanalytical Chemistry 411 (16): 3561–3579. June 2019. doi:10.1007/s00216-019-01837-8. PMID 31183523.
- ↑ "Metabolism of the new synthetic cannabinoid EG-018 in human hepatocytes by high-resolution mass spectrometry". Forensic Toxicology 36 (2): 304–312. July 2018. doi:10.1007/s11419-018-0404-2. ISSN 1860-8973.
- ↑ "In vitro and in vivo pharmacological evaluation of the synthetic cannabinoid receptor agonist EG-018". Pharmacology, Biochemistry, and Behavior 193: 172918. June 2020. doi:10.1016/j.pbb.2020.172918. PMID 32247816.
- ↑ "指定薬物を指定する省令が公布されました｜厚生労働省". Ministry of Health, Labour and Welfare. https://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/oshirase/20191114-1.html.
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