Chemistry:Tegileridine
From HandWiki
Tegileridine, sold under the brand name Aisute, is a drug which acts as a μ-opioid receptor agonist. It is closely related to compounds such as oliceridine, TRV734, and SHR9352, and shares a similar profile as a biased agonist selective for activation of the G protein signalling pathway over β-arrestin2 recruitment.[1]
In January 2024, tegileridine was approved in China under the brand name Aisute for the treatment of moderate to severe pain after abdominal surgery.[2]
See also
- μ-Opioid receptor § Biased agonists
References
- ↑ "Oxa spiro derivative, preparation method therefor, and applications thereof in medicines" WO patent 2017/063509, published 10 April 2018, assigned to Jiangsu Hengrui Medicine Companyand Shanghai Hengrui Pharmaceutical Company Ltd .
- ↑ "Tegileridine: First Approval". Drugs 84 (6): 717–720. June 2024. doi:10.1007/s40265-024-02033-4. PMID 38771484.
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