Chemistry:BD-1047
From HandWiki
BD-1047 is a sigma receptor antagonist, selective for the σ1 subtype. It has effects in animal studies suggestive of antipsychotic activity and may also be useful in the treatment of neuropathic pain.[1][2]
More recent studies also suggest a novel role for BD-1047 in attenuating ethanol-induced neurotoxicity in vitro, and additional research is being conducted on this compound as a possible pharmacotherapy for alcohol use disorder (AUD) [3]
References
- ↑ "Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity". Pharmacological Reports 58 (5): 626–35. 2006. PMID 17085854.
- ↑ "Intrathecal injection of the sigma(1) receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain". Anesthesiology 109 (5): 879–89. November 2008. doi:10.1097/ALN.0b013e3181895a83. PMID 18946301.
- ↑ "Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3.". Alcohol Clin Exp Res 40 (7): 1454–61. 2016. doi:10.1111/acer.13097. PMID 27177604.
 |  |
