Chemistry:DPH-362

From HandWiki

DPH-362 is a simplified amitriptyline analog created by omission of the two-carbon dibenzosuberane bridge (the seven membered ring). The resulting compound still had activity in a test to explore TCA sodium channel blockers with analgesic properties.[1][2]

It is based on previous structures such as Spasmolytic A29 (one of the active ingredients in Ketogan)[3][4] and SKF-89976A.

See also

References

  1. ↑ "Voltage-gated sodium channel blockers, 2001-2006: An overview.". Medicinal Chemistry Research 17 (2–7): 356–368. June 2008. doi:10.1007/s00044-007-9071-2. 
  2. ↑ "Discovery of diphenyl amine based sodium channel blockers, effective against hNav1.2". Bioorganic & Medicinal Chemistry 14 (24): 8366–8378. December 2006. doi:10.1016/j.bmc.2006.09.010. PMID 17035036. 
  3. ↑ "Studies on a new spasmolytic compound 1,1-diphenyl-3-dimethylaminobutene-1 (A29), related to methadone, and on the combined use of this compound and a potent analgesic, ketobemidone (A21)". Acta Pharmacologica et Toxicologica 7 (1): 51–64. 1951. doi:10.1111/j.1600-0773.1951.tb02849.x. PMID 14829296. 
  4. ↑ "Opioid analgesics as noncompetitive N-methyl-D-aspartate (NMDA) antagonists". Biochemical Pharmacology 56 (5): 553–559. September 1998. doi:10.1016/s0006-2952(98)00088-4. PMID 9783723. 




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