Chemistry:N-Acetyl-γ-aminobutyric acid

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Short description: Endogenous GABA precursor


N-Acetyl-γ-aminobutyric acid
Names
IUPAC name
4-acetamidobutanoic acid
Other names
N-Acetyl-GABA; N-Acetyl-4-aminobutyric acid
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
EC Number
  • 221-186-1
KEGG
UNII
Properties
C6H11NO3
Molar mass 145.158 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

N-Acetyl-γ-aminobutyric acid (N-acetyl-GABA), also known as N-acetyl-4-aminobutyric acid, is a metabolic intermediate in the biosynthesis of γ-aminobutyric acid (GABA) from putrescine.[1][2][3][4] Other intermediates in this pathway include N-acetylputrescine and N-acetyl-γ-aminobutyraldehyde (N-acetyl-GABAL or N-acetyl-GABA aldehyde).[2][3][4] Enzymes mediating the transformations in this pathway include putrescine acetyltransferase (PAT), monoamine oxidase B (MAO-B), aldehyde dehydrogenase (ALDH), and an unknown deacetylase enzyme.[2][3][4] The pathway is a minor pathway in GABA synthesis compared to the main pathway in which GABA is synthesized from glutamate.[2][3][4] However, the pathway has been found to have an important physiological role in the brain, for instance in the production of GABA in the striatum and resultant inhibition of dopaminergic neurons in this brain area.[1][4]

References

  1. ↑ 1.0 1.1 "Revisiting the Role of Astrocytic MAOB in Parkinson's Disease". Int J Mol Sci 23 (8): 4453. April 2022. doi:10.3390/ijms23084453. PMID 35457272. 
  2. ↑ 2.0 2.1 2.2 2.3 "GABA and GABA Receptors in the Central Nervous System and Other Organs". A Survey of Cell Biology. International Review of Cytology. 213. 2002. pp. 1–47. doi:10.1016/s0074-7696(02)13011-7. ISBN 978-0-12-364617-0. 
  3. ↑ 3.0 3.1 3.2 3.3 "Catabolism of polyamines". Amino Acids 26 (3): 217–233. June 2004. doi:10.1007/s00726-004-0070-z. PMID 15221502. 
  4. ↑ 4.0 4.1 4.2 4.3 4.4 "Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis". Exp Mol Med 53 (7): 1148–1158. July 2021. doi:10.1038/s12276-021-00646-3. PMID 34244591. 

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See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators

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