Biology:Granulocyte colony-stimulating factor receptor
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene.[1] G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF).[2] The G-CSF receptors belong to a family of cytokine receptors known as the hematopoietin receptor family. The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.
The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.
Isoforms
The class IV isoform defective for both internalization and differentiation signaling,[3] and colony-stimulating.
Clinical significance
Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.[4]
Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.[5]
In clinical medicine, there is a suggestion that use of GCSF should be avoided, at least in children and adolescents and perhaps adults, when G-CSFR isoform IV is overexpressed.[6]
Interactions
Granulocyte colony-stimulating factor receptor has been shown to interact with Grb2,[7] HCK[8] and SHC1.[7]
See also
References
- ↑ "Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34". Blood 79 (5): 1148–54. March 1992. doi:10.1182/blood.V79.5.1148.1148. PMID 1371413.
- ↑ "Entrez Gene: CSF3R colony stimulating factor 3 receptor (granulocyte)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1441.
- ↑ Mehta, H M; Futami, M; Glaubach, T; Lee, D W; Andolina, J R; Yang, Q; Whichard, Z; Quinn, M et al. (May 2014). "Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition". Leukemia 28 (5): 1041–1051. doi:10.1038/leu.2013.321. ISSN 1476-5551. PMID 24170028.
- ↑ "Kostmann syndrome and severe congenital neutropenia". Semin. Hematol. 39 (2): 82–8. April 2002. doi:10.1053/shem.2002.31913. PMID 11957189.
- ↑ "G-CSF and its receptor in myeloid malignancy". Blood 115 (25): 5131–6. June 2010. doi:10.1182/blood-2010-01-234120. PMID 20237318.
- ↑ "Granulocyte colony-stimulating factor (G-CSF) treatment of childhood acute myeloid leukemias that overexpress the differentiation-defective G-CSF receptor isoform IV is associated with a higher incidence of relapse". J. Clin. Oncol. 28 (15): 2591–7. May 2010. doi:10.1200/JCO.2009.25.9010. PMID 20406937.
- ↑ 7.0 7.1 "Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor". Biochim. Biophys. Acta 1448 (1): 70–6. November 1998. doi:10.1016/S0167-4889(98)00120-7. PMID 9824671.
- ↑ "The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor". Biochem. Biophys. Res. Commun. 251 (1): 117–23. October 1998. doi:10.1006/bbrc.1998.9441. PMID 9790917.
Further reading
- "Expression of G-CSF receptor on myeloid progenitors.". Leuk. Lymphoma 42 (6): 1351–7. 2002. doi:10.3109/10428190109097763. PMID 11911419.
- "Granulocyte colony-stimulating factor receptors on CD34++ cells in patients with myelodysplastic syndrome (MDS) and MDS-acute myeloid leukemia.". Leuk. Lymphoma 45 (10): 1995–2000. 2005. doi:10.1080/10428190410001714034. PMID 15370243.
- "Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34.". Blood 79 (5): 1148–54. 1992. doi:10.1182/blood.V79.5.1148.1148. PMID 1371413.
- "Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor.". J. Immunol. 148 (1): 259–66. 1992. doi:10.4049/jimmunol.148.1.259. PMID 1530796.
- "Three different mRNAs encoding human granulocyte colony-stimulating factor receptor.". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8702–6. 1991. doi:10.1073/pnas.87.22.8702. PMID 1701053.
- "Functional domains of the granulocyte colony-stimulating factor receptor.". EMBO J. 10 (10): 2855–65. 1991. doi:10.1002/j.1460-2075.1991.tb07835.x. PMID 1717255.
- "Assignment of the human granulocyte colony-stimulating factor receptor gene (CSF3R) to chromosome 1 at region p35-p34.3.". Genomics 10 (4): 1075–8. 1991. doi:10.1016/0888-7543(91)90202-P. PMID 1833306.
- "Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains.". J. Exp. Med. 172 (6): 1559–70. 1991. doi:10.1084/jem.172.6.1559. PMID 2147944.
- "Identification and characterization of receptors for granulocyte colony-stimulating factor on human placenta and trophoblastic cells.". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9323–6. 1990. doi:10.1073/pnas.86.23.9323. PMID 2480598.
- "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 2985–8. 1994. doi:10.1073/pnas.91.8.2985. PMID 7512720. Bibcode: 1994PNAS...91.2985N.
- "Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia.". Proc. Natl. Acad. Sci. U.S.A. 91 (10): 4480–4. 1994. doi:10.1073/pnas.91.10.4480. PMID 7514305. Bibcode: 1994PNAS...91.4480D.
- "Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia.". N. Engl. J. Med. 333 (8): 487–93. 1995. doi:10.1056/NEJM199508243330804. PMID 7542747. http://repub.eur.nl/pub/60338.
- "Identification of a functional receptor for granulocyte colony-stimulating factor on platelets.". J. Clin. Invest. 91 (4): 1310–3. 1993. doi:10.1172/JCI116330. PMID 7682568.
- "The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain.". J. Biol. Chem. 270 (23): 13814–8. 1995. doi:10.1074/jbc.270.23.13814. PMID 7775438.
- "Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 4683–7. 1994. doi:10.1073/pnas.91.11.4683. PMID 8197119. Bibcode: 1994PNAS...91.4683C.
- "Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region.". Arch. Biochem. Biophys. 324 (2): 344–56. 1996. doi:10.1006/abbi.1995.0047. PMID 8554326.
- "Dimerization of the extracellular domain of granuloycte-colony stimulating factor receptor by ligand binding: a monovalent ligand induces 2:2 complexes.". Biochemistry 35 (15): 4886–96. 1996. doi:10.1021/bi9525841. PMID 8664280.
- "Expression of granulocyte-colony stimulating factor and its receptor is regulated during the development of the human placenta.". J. Endocrinol. 149 (2): 249–58. 1996. doi:10.1677/joe.0.1490249. PMID 8708536.
- "Disulfide structure and N-glycosylation sites of an extracellular domain of granulocyte-colony stimulating factor receptor.". Biochemistry 35 (40): 13040–6. 1996. doi:10.1021/bi960213u. PMID 8855939.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
External links
- CSF3R+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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