Chemistry:(R,R)-Tetrahydrochrysene
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Short description: Chemical compound
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| Formula | C22H24O2 |
| Molar mass | 320.432 g·mol−1 |
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(R,R)-Tetrahydrochrysene ((R,R)-THC) is a drug used to study the estrogen receptors (ERs) in scientific research. It is an ERβ antagonist and an ERα agonist with 10-fold higher affinity for ERβ relative to ERα.[1][2] (R,R)-THC is a silent antagonist of ERβ,[3] and, uniquely relative to other known ERβ antagonists, a passive antagonist of the receptor.[2]
(S,S)-Tetrahydrochrysene ((S,S)-THC) also binds to the ERs, but in contrast to (R,R)-THC, (S,S)-THC is an agonist of both ERα and ERβ and has 20-fold lower affinity for ERβ relative to (R,R)-THC.[3]
See also
- Propylpyrazoletriol (PPT)
- PHTPP
- Methylpiperidinopyrazole (MPP)
- Diarylpropionitrile (DPN)
- Prinaberel (ERB-041)
- Liquiritigenin
- Menerba
- 2,8-DHHHC
- Chrysene
References
- ↑ Ying Chen (2008). The Role of Steroids in the Regulation of Oocyte Cyst Breakdown and Primordial Follicle Assembly in the Neonatal Mouse Ovary. Syracuse University. pp. 101–. ISBN 978-0-549-74620-1. https://books.google.com/books?id=uf2VdCOO6moC&pg=PA101.
- ↑ 2.0 2.1 "Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism". Nat. Struct. Biol. 9 (5): 359–64. 2002. doi:10.1038/nsb787. PMID 11953755.
- ↑ 3.0 3.1 "Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta". Endocrinology 140 (2): 800–4. 1999. doi:10.1210/endo.140.2.6480. PMID 9927308.
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