Chemistry:FERb 033
From HandWiki
Short description: Chemical compound
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| Formula | C13H9ClFNO3 |
| Molar mass | 281.67 g·mol−1 |
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FERb 033 is a synthetic, nonsteroidal estrogen that was synthesized in 2009 and is used in scientific research.[1][2] It is a potent and selective ERβ agonist (Ki = 7.1 nM, EC50 = 4.8 nM), with 62-fold selectivity for the ERβ over the ERα.[1][2]
See also
References
- ↑ 1.0 1.1 "Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta". J. Med. Chem. 52 (3): 858–67. 2009. doi:10.1021/jm801458t. PMID 19128016.
- ↑ 2.0 2.1 "ERβ1: characterization, prognosis, and evaluation of treatment strategies in ERα-positive and -negative breast cancer". BMC Cancer 14: 749. 2014. doi:10.1186/1471-2407-14-749. PMID 25288324.
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