Chemistry:Prinaberel
From HandWiki
Short description: Chemical compound
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| Formula | C15H10FNO3 |
| Molar mass | 271.247 g·mol−1 |
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Prinaberel (INN, USAN) (developmental code names ERB-041, WAY-202041) is a synthetic, nonsteroidal, and highly selective agonist of the ERβ subtype of the estrogen receptor.[1] It is used in scientific research to elucidate the role of the ERβ receptor.[2] Studies have indicated that selective ERβ agonists like prinaberel could be useful in the clinical treatment of a variety of medical conditions including inflammatory bowel disease, rheumatoid arthritis, endometriosis, and sepsis.[3] Accordingly, prinaberel either was or still is under investigation by Wyeth for the treatment of some of these conditions.[4]
See also
References
- ↑ "Evaluation of an estrogen receptor-beta agonist in animal models of human disease". Endocrinology 144 (10): 4241–9. October 2003. doi:10.1210/en.2003-0550. PMID 14500559. http://endo.endojournals.org/cgi/pmidlookup?view=long&pmid=14500559.
- ↑ "Reflections on the discovery and significance of estrogen receptor beta". Endocrine Reviews 26 (3): 465–78. May 2005. doi:10.1210/er.2004-0027. PMID 15857973. http://edrv.endojournals.org/cgi/pmidlookup?view=long&pmid=15857973.
- ↑ Harris HA (2006). "Preclinical characterization of selective estrogen receptor beta agonists: new insights into their therapeutic potential". Ernst Schering Foundation Symposium Proceedings 2006/1 (1): 149–61. doi:10.1007/2789_2006_021. ISBN 978-3-540-49547-5. PMID 17824176.
- ↑ "Prinaberel - Wyeth phase change II, USA (endometriosis)". R & D Focus Drug News. 2006-06-05. http://business.highbeam.com/436989/article-1G1-146524305/prinaberel-wyeth-phase-change-ii-usa.
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