Chemistry:ICI-85966
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Short description: Chemical compound
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| Other names | Stilbostat; Diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate) |
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| Formula | C28H34Cl4N2O4 |
| Molar mass | 604.39 g·mol−1 |
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ICI-85966 (former tentative brand name Stilbostat), also known as diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate), is a synthetic, nonsteroidal estrogen and cytostatic antineoplastic agent of the stilbestrol group and a nitrogen mustard ester of diethylstilbestrol (DES) which was developed for the treatment of breast cancer and prostate cancer but was never marketed (possibly due to the toxicity of DES).[1][2][3][4][5]
See also
References
- ↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 397. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA397.
- ↑ "[Therapeutic effects of the preparation "Stilbostat" in advanced stages of breast cancer after the menopause]" (in ro). Stud Cercet Endocrinol 24 (3): 211–9. 1973. PMID 4703920.
- ↑ "Contribution to the mechanism of Stilbostat action". Neoplasma 23 (4): 363–9. 1976. PMID 1004653.
- ↑ "Estimation of StilbostatR treatment efficiency in breast cancer by thermography". Neoplasma 24 (5): 553–7. 1977. PMID 927612.
- ↑ "Treatment of prostatic carcinoma with Stilbostat". Neoplasma 21 (1): 101–8. 1974. PMID 4596007.
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