Chemistry:Methylpiperidinopyrazole
From HandWiki
Short description: Chemical compound
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| Formula | C29H31N3O3 |
| Molar mass | 469.585 g·mol−1 |
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Methylpiperidinopyrazole (MPP) is a synthetic, nonsteroidal, and highly selective antagonist of ERα that is used in scientific research to study the function of this receptor.[1][2] It has 200-fold selectivity for ERα over ERβ and 1000-fold selectivity for blocking ERα-mediated gene transcription relative to that of ERβ.[3]
See also
- Glyceollin
- Propylpyrazoletriol (PPT)
- Diarylpropionitrile (DPN)
- Prinaberel (ERB-041)
- Liquiritigenin
- Menerba
- PHTPP
- (R,R)-Tetrahydrochrysene ((R,R)-THC)
References
- ↑ "Antagonists selective for estrogen receptor alpha". Endocrinology 143 (3): 941–7. March 2002. doi:10.1210/endo.143.3.8704. PMID 11861516.
- ↑ "Analogs of methyl-piperidinopyrazole (MPP): antiestrogens with estrogen receptor alpha selective activity". Bioorganic & Medicinal Chemistry Letters 19 (1): 108–10. January 2009. doi:10.1016/j.bmcl.2008.11.006. PMID 19014882.
- ↑ Nuclear Receptors as Drug Targets. John Wiley & Sons. 8 September 2008. pp. 50–. ISBN 978-3-527-62330-3. https://books.google.com/books?id=iATfLbPgRugC&pg=PA50.
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