Chemistry:ERB-196
From HandWiki
Short description: Chemical compound
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| Other names | WAY-202196 |
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| Formula | C17H10FNO2 |
| Molar mass | 279.270 g·mol−1 |
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ERB-196, also known as WAY-202196, is a synthetic nonsteroidal estrogen that acts as a highly selective agonist of the ERβ.[1][2][3][4][5][6] It possesses 78-fold selectivity for the ERβ over the ERα.[1] The drug was under development by Wyeth for the treatment of inflammation and sepsis starting in 2004 but development was discontinued by 2011.[2][7]
See also
References
- ↑ 1.0 1.1 "Isoform Specificity: The Design of Estrogen Receptor-β Selective Compounds". Structure-based Drug Discovery: An Overview. Royal Society of Chemistry. 2006. pp. 241–. ISBN 978-0-85404-351-4. https://books.google.com/books?id=Q_Kj1Qvgob4C&pg=PA241.
- ↑ 2.0 2.1 "ERB 196". AdisInsight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800021229.
- ↑ "Estradiol". Estrogens—Advances in Research and Application. ScholarlyEditions. 2013. pp. 52–. ISBN 978-1-4816-8771-3. https://books.google.com/books?id=NYW4rG83zrUC&pg=PA52.
- ↑ "Untangling the Estrogen Receptor Web: Tools to Selectively Study Estrogen-Binding Receptors". Nuclear Receptors as Drug Targets. Methods and Principles in Medicinal Chemistry. John Wiley & Sons. 8 September 2008. pp. 66–. doi:10.1002/9783527623297.ch3. ISBN 978-3-527-62330-3. https://books.google.com/books?id=iATfLbPgRugC&pg=PA66.
- ↑ "ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity". Journal of Medicinal Chemistry 48 (12): 3953–3979. June 2005. doi:10.1021/jm058173s. PMID 15943471.
- ↑ "WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock". Critical Care Medicine 34 (8): 2188–2193. August 2006. doi:10.1097/01.CCM.0000227173.13497.56. PMID 16755255.
- ↑ "Influence of Gender on Outcome of Severe Sepsis". Yearbook of Intensive Care and Emergency Medicine 2007. Springer Science & Business Media. 8 December 2007. pp. 891–. ISBN 978-3-540-49433-1. https://books.google.com/books?id=zT8_AAAAQBAJ&pg=PA891.
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