Chemistry:2,8-Dihydroxyhexahydrochrysene

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Short description: Chemical compound
2,8-Dihydroxyhexahydrochrysene
2,8-Dihydroxyhexahydrochrysene.svg
Clinical data
ATC code
  • None
Chemical and physical data
FormulaC18H18O2
Molar mass266.340 g·mol−1

2,8-Dihydroxyhexahydrochrysene (2,8-DHHHC) is a synthetic, nonsteroidal weak estrogen with approximately 1/2,000th the estrogenic potency of the structurally-related estrogen diethylstilbestrol.[1][2][3] It is said to be intermediate in structure between estradiol and hexestrol, but conversely to both of them, it is drastically less potent in comparison.[3]

See also

References

  1. ↑ Tamoxifen: Pioneering Medicine in Breast Cancer. Springer Science & Business Media. 23 July 2013. pp. 4–. ISBN 978-3-0348-0664-0. https://books.google.com/books?id=p-W5BAAAQBAJ&pg=PA4. 
  2. ↑ Jordan, Virgil Craig (1986). Estrogen/antiestrogen Action and Breast Cancer Therapy. Univ of Wisconsin Press. pp. 22–. ISBN 978-0-299-10480-1. https://books.google.com/books?id=7WmLZfGXST0C&pg=PA22. 
  3. ↑ 3.0 3.1 "Cyclic Analogs of Hexestrol in the Chrysene Series". The Journal of Organic Chemistry 16 (9): 1371–1379. 1951. doi:10.1021/jo50003a006. ISSN 0022-3263. 




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