Chemistry:Hippulin
From HandWiki
Short description: Chemical compound
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| Other names | Δ8-14-Isoestrone; 8-Dehydro-14-isoestrone; 14-Isoestra-1,3,5(10),8-tetraen-3-ol-17-one |
| Routes of administration | By mouth |
| Drug class | Estrogen |
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| Formula | C18H20O2 |
| Molar mass | 268.356 g·mol−1 |
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Hippulin, also known as Δ8-14-isoestrone, as well as 14-isoestra-1,3,5(10),8-tetraen-3-ol-17-one, is a naturally occurring estrogen found in horses and an isomer of equilin.[1][2][3][4] The compound, likely in sodium sulfate form, is a component of conjugated estrogens (Premarin), a pharmaceutical extract of the urine of pregnant mares,[1][2][3] though it is present only in small amounts in pregnant mare urine.[5] It has been reported by possess either equivalent estrogenic activity to that of equilin or only slight estrogenic activity.[3] The compound was first described in 1932.[4][3]
See also
References
- ↑ 1.0 1.1 C. W. Emmens (22 October 2013). Hormone Assay. Elsevier Science. pp. 391–. ISBN 978-1-4832-7286-3. https://books.google.com/books?id=cCzgBAAAQBAJ&pg=PA391.
- ↑ 2.0 2.1 H.J. Buchsbaum (6 December 2012). The Menopause. Springer Science & Business Media. pp. 56–. ISBN 978-1-4612-5525-3. https://books.google.com/books?id=z0LuBwAAQBAJ&pg=PA56.
- ↑ 3.0 3.1 3.2 3.3 "The resolution of isoequilin A and the identification of compound 3". J. Biol. Chem. 187 (2): 557–70. 1950. doi:10.1016/S0021-9258(18)56200-1. PMID 14803438. http://www.jbc.org/content/187/2/557.full.pdf.
- ↑ 4.0 4.1 Girard, H., Sandulesco, G., Fridenson, A., Gaudefroy, C., & Rutgers, J. J. (1932). Sur les Hormones Sexuelles Cristallisées Retirées de l'Urine des Juments Gravides. Compt. Rend. Acad. Sci, 194, 1020.
- ↑ Wintersteiner, O. (1937). "Estrogenic Diols from the Urine of Pregnant Mares". Cold Spring Harbor Symposia on Quantitative Biology 5: 25–33. doi:10.1101/SQB.1937.005.01.003. ISSN 0091-7451.
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