Chemistry:DCW234
From HandWiki
Short description: Chemical compound
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| Other names | Butyl 4-(butyryloxy)benzoate |
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| Formula | C15H20O4 |
| Molar mass | 264.321 g·mol−1 |
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DCW234, also known as butyl 4-(butyryloxy)benzoate, is a synthetic nonsteroidal estrogen and a selective agonist of the ERβ.[1][2][3] It shows modest selectivity in terms of affinity and transactivation for the ERβ over the ERα.[1] Its affinity for the ERβ was 3.43 μM and for the ERα was 22.5 μM, while it activated the ERβ and ERα with EC50 values of 1.71–2.5 μM and 19.8–22.5 μM, respectively.[1] As such, its binding selectivity for the ERβ over the ERα was 7-fold and its functional selectivity for the ERβ over the ERα was between 10- and 13-fold.[1]
See also
References
- ↑ 1.0 1.1 1.2 1.3 "Butyl 4-(butyryloxy)benzoate functions as a new selective estrogen receptor beta agonist and induces GLUT4 expression in CHO-K1 cells". J. Steroid Biochem. Mol. Biol. 110 (1–2): 150–6. 2008. doi:10.1016/j.jsbmb.2008.03.028. PMID 18455388.
- ↑ "Estrogen receptor β ligands: recent advances and biomedical applications". Med Res Rev 31 (3): 364–442. 2011. doi:10.1002/med.20186. PMID 19967775.
- ↑ "Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause". Recent Pat Cardiovasc Drug Discov 3 (3): 165–86. 2008. doi:10.2174/157489008786263970. PMID 18991792.
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