Chemistry:3α-Hydroxytibolone
From HandWiki
Short description: Chemical compound
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| Other names | ORG-4094; 7α-Methyl-17α-ethynylestr-5(10)-ene-3α,17β-diol |
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| Formula | C21H30O2 |
| Molar mass | 314.469 g·mol−1 |
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3α-Hydroxytibolone (developmental code name ORG-4094) is a synthetic steroidal estrogen which was never marketed.[1][2] Along with 3β-hydroxytibolone and δ4-tibolone, it is a major active metabolite of tibolone, and 3α-hydroxytibolone and 3β-hydroxytibolone are thought to be responsible for the estrogenic activity of tibolone.[1][2]
References
- ↑ 1.0 1.1 Kuhl, H (2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric 8 (sup1): 3–63. doi:10.1080/13697130500148875. ISSN 1369-7137. PMID 16112947.
- ↑ 2.0 2.1 "Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites". J. Steroid Biochem. Mol. Biol. 116 (1–2): 8–14. 2009. doi:10.1016/j.jsbmb.2009.03.008. PMID 19464167. http://www.hal.inserm.fr/inserm-00396319/document.
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