Chemistry:WAY-166818
From HandWiki
Short description: Chemical compound
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| Formula | C13H9NO3 |
| Molar mass | 227.219 g·mol−1 |
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WAY-166818 is a synthetic, nonsteroidal estrogen related to WAY-200070 which is used in scientific research.[1][2] It acts as a highly selective full agonist of the ERβ, with 57- and 164-fold selectivity for the ERβ over the ERα in the rat and mouse, respectively.[1][2] At the human ERβ and ERα, WAY-166818 has IC50 values of 29 nM and 1227 nM (25-fold difference), respectively.[1] The compound has been verified to cross the blood-brain-barrier in rodents.[1][2]
See also
References
- ↑ 1.0 1.1 1.2 1.3 "Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands". J. Med. Chem. 47 (21): 5021–40. 2004. doi:10.1021/jm049719y. PMID 15456246.
- ↑ 2.0 2.1 2.2 "Estrogen and estrogen receptor-{beta} (ER{beta})-selective ligands induce galanin expression within gonadotropin hormone-releasing hormone-immunoreactive neurons in the female rat brain". Endocrinology 146 (6): 2760–5. 2005. doi:10.1210/en.2004-1562. PMID 15790727.
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