Chemistry:Fispemifene
From HandWiki
Short description: Chemical compound
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| Other names | HM-101 |
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| Formula | C26H27ClO3 |
| Molar mass | 422.95 g·mol−1 |
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Fispemifene (INN, USAN) (developmental code name HM-101) is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that was developed for the treatment of male hypogonadism but was abandoned and never marketed.[1][2][3] It reached phase II clinical trials for this indication before development was terminated in March 2016.[1] The drug failed to achieve statistical significance on key effectiveness endpoints in clinical trials and was discontinued by its developer for strategic reasons.[1]
See also
References
- ↑ 1.0 1.1 1.2 "Fispemifene". AdisInsight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800013715.
- ↑ Selective Estrogen Receptor Modulators: A New Brand of Multitarget Drugs. Springer Science & Business Media. 22 September 2006. pp. 52–. ISBN 978-3-540-34742-2. https://books.google.com/books?id=heJDAAAAQBAJ&pg=PA52.
- ↑ Nuclear Receptors as Drug Targets. John Wiley & Sons. 8 September 2008. pp. 90–. ISBN 978-3-527-62330-3. https://books.google.com/books?id=iATfLbPgRugC&pg=PA90.
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