Chemistry:PHTPP
From HandWiki
Short description: Chemical compound
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| Formula | C20H11F6N3O |
| Molar mass | 423.318 g·mol−1 |
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PHTPP is a synthetic, nonsteroidal, and highly selective antagonist of ERβ that is used in scientific research to study the function of this receptor.[1][2] It possesses 36-fold selectivity for ERβ over ERα, and is a silent antagonist of ERβ.[3]
See also
- Propylpyrazoletriol (PPT)
- Methylpiperidinopyrazole (MPP)
- (R,R)-Tetrahydrochrysene ((R,R)-THC)
- Diarylpropionitrile (DPN)
- Prinaberel (ERB-041)
- Liquiritigenin
- Menerba
- WAY-200070
References
- ↑ Neurosteroids. Frontiers E-books. pp. 95–. ISBN 978-2-88919-078-2. https://books.google.com/books?id=fSgNRlZUwt0C&pg=PA95.
- ↑ Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012. pp. 220–. ISBN 978-1-4649-9741-9. https://books.google.com/books?id=AH0i2PG-MjsC&pg=PT220.
- ↑ "Pyrazolo[1,5-apyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity"]. Journal of Medicinal Chemistry 47 (24): 5872–93. November 2004. doi:10.1021/jm049631k. PMID 15537344. https://figshare.com/articles/Pyrazolo_1_5_i_a_i_pyrimidines_Estrogen_Receptor_Ligands_Possessing_Estrogen_Receptor_Antagonist_Activity/3315259.
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